منابع مشابه
Aerosolized Delivery of Antifungal Agents
Pulmonary infections caused by Aspergillus species are associated with significant morbidity and mortality in immunocompromised patients. Although the treatment of pulmonary fungal infections requires the use of systemic agents, aerosolized delivery is an attractive option in prevention because the drug can concentrate locally at the site of infection with minimal systemic exposure. Current cli...
متن کاملAntifungal Agents
Continued advancement of medical science offers life-saving treatment options for a variety of hematologic, oncologic, and rheumatologic conditions. Immunosuppression, a common therapeutic side-effect, predisposes patients to invasive fungal infections, which are escalating in prevalence. The development of effective, welltolerated antifungals has lagged behind the advances of antibacterial the...
متن کاملDelivery options and devices for aerosolized therapeutics.
Although inhalation is one of the oldest modes of drug delivery, it is currently receiving renewed attention. Prior to 1987, aerosolized therapeutics were delivered via systems that relied on chlorofluorocarbon propellant systems. The subsequent ban on all nonmedical uses of these inert gases stimulated pharmaceutical companies to investigate other propellant systems. Two hydrofluoroalkanes wer...
متن کاملAntifungal agents: Polyene, azole, antimetabolite, other and future agents
Antifungals have always been considered as one of the astonishing discoveries of the 20th century. This is correct, but the real marvel is the development of antifungal resistance in hospitals, communities, and the environment concomitant with their use. Fungal infections have emerged as an important clinical threat, with significant associated morbidity and mortality. This study is desig...
متن کاملLipid-based antifungal agents.
The spectrum of human mycoses ranges from superficial and local to disseminated and life-threatening infections. Opportunistic fungal infections of the immunocompromised host are difficult to treat and result in significant mortality. Antifungal drugs with a broad spectrum of activity along with acceptable efficacy and an optimal safety profile are an option for the treatment of these infection...
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ژورنال
عنوان ژورنال: Current Fungal Infection Reports
سال: 2010
ISSN: 1936-3761,1936-377X
DOI: 10.1007/s12281-010-0011-0